Luis Paz-Ares Selected Research

Gemcitabine

1/2017	Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors.
7/2015	Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial.
1/2014	Randomized, double-blind, phase II trial comparing gemcitabine-cisplatin plus the LTB4 antagonist LY293111 versus gemcitabine-cisplatin plus placebo in first-line non-small-cell lung cancer.
4/2012	Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC Intergroup Study 30987.
10/2010	Safety and resource utilization by non-small cell lung cancer histology: results from the randomized phase III study of pemetrexed plus cisplatin versus gemcitabine plus cisplatin in chemonaïve patients with advanced non-small cell lung cancer.
3/2006	Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer.
8/2002	Pretreatment prognostic factors for survival in patients with advanced urothelial tumors treated in a phase I/II trial with paclitaxel, cisplatin, and gemcitabine.

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Luis Paz-Ares Research Topics

Disease

132	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2024 - 12/2004
122	Neoplasms (Cancer) 04/2024 - 05/2002
52	Lung Neoplasms (Lung Cancer) 04/2024 - 06/2007
46	Disease Progression 01/2024 - 04/2005
21	Neutropenia 04/2024 - 05/2002
20	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 04/2024 - 06/2007
18	Neoplasm Metastasis (Metastasis) 12/2023 - 08/2002
12	Adenocarcinoma 08/2023 - 05/2013
12	Carcinoma (Carcinomatosis) 01/2023 - 08/2002
11	Adenocarcinoma of Lung 09/2023 - 06/2014
11	Exanthema (Rash) 01/2017 - 12/2004
9	Febrile Neutropenia 12/2023 - 06/2004
8	Colorectal Neoplasms (Colorectal Cancer) 05/2024 - 05/2007
7	Thrombocytopenia (Thrombopenia) 12/2023 - 04/2012
7	Body Weight (Weight, Body) 08/2023 - 07/2015
7	Fatigue 01/2023 - 03/2012
6	Pneumonia (Pneumonitis) 11/2022 - 11/2017
5	Anemia 04/2024 - 03/2013
5	Carcinogenesis 08/2023 - 01/2015
5	Breast Neoplasms (Breast Cancer) 11/2022 - 08/2013
5	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2022 - 05/2013
4	Diarrhea 04/2024 - 01/2008
4	Brain Neoplasms (Brain Tumor) 12/2023 - 01/2017
4	Chest Pain (Chest Pains) 12/2023 - 01/2020
4	Dyspnea (Shortness of Breath) 12/2023 - 01/2020
4	Melanoma (Melanoma, Malignant) 08/2023 - 03/2009
4	Asthenia 01/2021 - 01/2008
4	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 04/2012
4	Nausea 01/2019 - 11/2014
3	Leukopenia 04/2024 - 01/2019
3	Thyroid Neoplasms (Thyroid Cancer) 11/2023 - 02/2010
3	Ovarian Neoplasms (Ovarian Cancer) 01/2023 - 02/2015
3	Interstitial Lung Diseases (Interstitial Lung Disease) 11/2022 - 01/2019
3	Cough 10/2021 - 01/2020
3	Fever (Fevers) 12/2019 - 05/2002
3	Stomatitis 01/2019 - 11/2014
3	Chronic Obstructive Pulmonary Disease (COPD) 12/2016 - 02/2013
3	Acne Vulgaris 01/2016 - 01/2011
3	Pathologic Processes 09/2014 - 01/2012

Drug/Important Bio-Agent (IBA)

51	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2011
41	PlatinumIBA 04/2024 - 01/2005
27	ErbB Receptors (EGF Receptor)IBA 12/2023 - 06/2007
24	Cisplatin (Platino)FDA LinkGeneric 10/2023 - 08/2002
24	Proteins (Proteins, Gene)FDA Link 09/2023 - 06/2010
18	Tyrosine Kinase InhibitorsIBA 12/2023 - 01/2008
17	pembrolizumabIBA 04/2024 - 11/2018
17	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2023 - 06/2007
15	NivolumabIBA 02/2024 - 07/2015
15	Carboplatin (JM8)FDA LinkGeneric 10/2023 - 12/2004
14	Pemetrexed (MTA)FDA Link 02/2024 - 12/2002
14	durvalumabIBA 10/2023 - 11/2017
13	Messenger RNA (mRNA)IBA 04/2024 - 07/2007
12	B7-H1 AntigenIBA 01/2024 - 08/2017
12	Immune Checkpoint InhibitorsIBA 12/2023 - 06/2015
11	LigandsIBA 04/2024 - 10/2015
9	Docetaxel (Taxotere)FDA Link 01/2024 - 07/2007
9	Paclitaxel (Taxol)FDA LinkGeneric 10/2023 - 08/2002
8	Phosphotransferases (Kinase)IBA 06/2023 - 06/2010
8	RamucirumabIBA 01/2023 - 01/2017
7	IpilimumabIBA 02/2024 - 05/2018
7	PM 01183IBA 12/2023 - 01/2017
7	Etoposide (VP 16)FDA LinkGeneric 10/2023 - 11/2017
7	MicroRNAs (MicroRNA)IBA 02/2023 - 01/2012
7	AfatinibIBA 01/2022 - 01/2016
7	necitumumabIBA 03/2019 - 03/2015
7	Gemcitabine FDA Link 01/2017 - 08/2002
6	Alanine Transaminase (SGPT)IBA 01/2020 - 05/2007
6	Gefitinib (Iressa)FDA Link 01/2020 - 09/2009
5	Irinotecan (Camptosar)FDA LinkGeneric 04/2024 - 05/2005
5	Cetuximab (Erbitux)FDA Link 12/2023 - 01/2011
5	Anaplastic Lymphoma KinaseIBA 07/2023 - 05/2012
5	Transaminases (Aminotransferases)IBA 11/2022 - 05/2007
5	Monoclonal AntibodiesIBA 06/2022 - 08/2017
5	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2020 - 06/2010
4	Topotecan (Hycamtin)FDA LinkGeneric 04/2024 - 01/2019
4	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 05/2015
4	AntibodiesIBA 10/2022 - 01/2014
4	CytokinesIBA 03/2021 - 01/2016
3	canakinumab FDA Link 01/2024 - 10/2023
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2023 - 01/2019
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2023 - 01/2019
3	abemaciclibIBA 11/2022 - 01/2016
3	EnzymesIBA 03/2021 - 01/2016
3	Cadherins (E-Cadherin)IBA 03/2021 - 01/2018
3	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2020 - 05/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2019 - 04/2013
3	TrabectedinIBA 09/2012 - 05/2007
3	Fluorouracil (Carac)FDA LinkGeneric 01/2008 - 05/2005
2	atezolizumabIBA 05/2024 - 08/2017
2	sotorasibIBA 01/2024 - 01/2023
2	InterleukinsIBA 12/2023 - 10/2023

Therapy/Procedure

78	Therapeutics 04/2024 - 07/2007
77	Drug Therapy (Chemotherapy) 04/2024 - 05/2002
16	Immunotherapy 04/2024 - 07/2015
7	Chemoradiotherapy 12/2022 - 12/2005
5	Radiotherapy 06/2022 - 06/2007
4	Precision Medicine 01/2023 - 01/2017
3	Adjuvant Chemotherapy 10/2022 - 01/2017
3	Aftercare (After-Treatment) 01/2020 - 10/2016
3	TP protocol 04/2012 - 08/2002